UK launches first adaptive Alzheimer's drug trial
Summarised from 2 outlets · Updated 24 Oct, 16:32 · Archive
The AD-SMART study is the first UK Alzheimer's trial to test multiple treatments simultaneously using an adaptive platform design.
The AD-SMART study represents a new approach to Alzheimer's drug testing in the UK. Led by the UK Dementia Research Institute and Alzheimer's Research UK, the trial uses a multi-arm adaptive platform design that enables researchers to test multiple treatments simultaneously and quickly identify the most promising options.
The trial compares several potential treatments against a shared placebo group, allowing researchers to rule out ineffective therapies sooner and introduce new candidate drugs as the study evolves. This approach is expected to reduce the time needed to test potential Alzheimer's drugs by more than half compared to traditional clinical trials.
The first treatments to be tested are two repurposed drugs already licensed for type 2 diabetes and attention deficit hyperactivity disorder (ADHD). Because these medicines are already known to be safe, any positive results could reach patients more quickly than newly developed drugs. Dementias Platform UK is supporting the trial by using its existing network of sites and Blood Biomarker Challenge READ-OUT study data to help recruit participants.
How it is being reported
- Oxford researchers join groundbreaking Alzheimer's drug trialThe trial brings together experts from across the country, including teams from the University of Oxford and Dementias Platform UK (DPUK).Oxford Mail · 24 Oct, 16:00
- Oxford researchers join groundbreaking Alzheimer's drug trialThe trial brings together experts from across the country, including teams from the University of Oxford and Dementias Platform UK (DPUK).Oxfordshire Guardian · 24 Oct, 16:00
In this story: University of Oxford · Dementias Platform UK · UK Dementia Research Institute · Alzheimer's Research UK · Vanessa Raymont · Oxford Health
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